Thursday, February 28, 2013

Julie?s Gadget Diary ? My evolving EDC

I thought it might be interesting and useful for me to capture a visual and text list of my EDC (Every Day Carry) gear on a monthly basis. Seeing my gear might give you ideas for your own EDC and I’m hoping you might make suggestions for things I should look at that might replace [...]

Source: http://the-gadgeteer.com/2013/02/28/julies-gadget-diary-my-evolving-edc/

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Glamorous Diana dresses up for auction

AAA??Feb. 28, 2013?7:41 AM ET
Glamorous Diana dresses up for auction
AP

The beaded neckline of a Catherine Walker black velvet evening gown worn for a Vanity Fair photo shoot by Britain's Princess Diana is adjusted by house assistant Lucy Bishop at the Kerry Taylor auction rooms in London, Thursday, Feb. 28, 2013. The dress estimated to realise 50,000-70,000 pounds ( 77,000-108,000 US Dollars) will be sold in the Fit For a Princess auction in London on March 19. (AP Photo/Kirsty Wigglesworth)

The beaded neckline of a Catherine Walker black velvet evening gown worn for a Vanity Fair photo shoot by Britain's Princess Diana is adjusted by house assistant Lucy Bishop at the Kerry Taylor auction rooms in London, Thursday, Feb. 28, 2013. The dress estimated to realise 50,000-70,000 pounds ( 77,000-108,000 US Dollars) will be sold in the Fit For a Princess auction in London on March 19. (AP Photo/Kirsty Wigglesworth)

A Victor Edelstein midnight-blue velvet evening gown worn by Britain's Princess Diana when she danced with actor John Travolta in 1985 at the State dinner at the White House given by President and Mrs Reagan, is adjusted by house assistant Lucy Bishop at the Kerry Taylor auction rooms in London, Thursday, Feb. 28, 2013. The dress estimated to realise 200,000-300,000 pounds ( 310,000-464,000 US Dollars) will be sold in the Fit For a Princess auction in London on March 19. (AP Photo/Kirsty Wigglesworth)

A Catherine Walker sea-green sequined evening gown worn for the State visit to Austria by Britain's Princess Diana is adjusted by house assistant Lucy Bishop at the Kerry Taylor auction rooms in London, Thursday, Feb. 28, 2013. The dress estimated to realise 30,000-50,000 pounds ( 46,000-77,000 US Dollars) will be sold in the Fit For a Princess auction in London on March 19. (AP Photo/Kirsty Wigglesworth)

Beading detail is shown on a Catherine Walker burgundy velvet sheath with embroidered tailcoat worn for the State visit to Korea in 1992 by Britain's Princess Diana, at the Kerry Taylor auction rooms in London, Thursday, Feb. 28, 2013. The dress estimated to realise 40,000-60,000 pounds ( 62,000-93,000 US Dollars) will be sold in the Fit For a Princess auction in London on March 19. (AP Photo/Kirsty Wigglesworth)

The bolero is adjusted on a Catherine Walker Mughal inspired embroidered pink silk evening gown made for Princess Diana's State visit to India in 1992, at Kerry Taylor auction rooms in London, Thursday, Feb. 28, 2013. The dress estimated to realise between 80,000-120,000 pounds (124,000- 186,000 US Dollars) will be sold in the Fit For a Princess auction in London on March 19. (AP Photo/Kirsty Wigglesworth)

(AP) ? If dresses could talk, this dark navy, figure-hugging velvet number would have the best stories to tell.

Princess Diana wore it on state visits, at royal banquets and most memorably to a gala dinner at the White House in 1985, when she took to the dance floor with Hollywood star John Travolta.

The Victor Edelstein gown will go under the hammer at a vintage fashion auction in London in March, along with nine other of Diana's lavish evening dresses. In total, Kerry Taylor Auctions say the sale is expected to raise more than 800,000 pounds ($1.2 million.)

The dresses, all in the signature 1980s look ? padded shoulders, puffed sleeves, crushed velvet ? are snapshots in the princess's glamorous, jet-setting life.

The sale is set for March 19.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-02-28-Britain-Diana's%20Dresses/id-3c2b32cb5f034a9ca1e6111659e7e3ab

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Chinese Buyers Snapping Up U.s. Real Estate - House Price Crash ...

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Make Grand Entry With South Bend Limo - Kirk Mcbride820's blog

By: Jennefer Kadarshan

A limo contributes charm and style to all the arrivals in entrance of a grand casino. A VIP entry boosts up your confidence and impresses the other casino's visitors. The South Bend limo is a very popular transport automobile associated with important events or other activities where a sophisticated entry is a must. Rich people, celebrities and superstars generally used to travel by limos to the casino. Either offered by one of the limo companies or the casino itself, the high-class limo is now cost-effective to most of the individuals. As per the price range assigned, it is possible to seek the services of any chauffeured limo that meets individual choices and needs.
Before determining and booking the any Limousine service it is greatly advice to and checks out the limo and the interior to make sure it is cleaned and properly serviced, this will help you to decide, satisfy your needs and prevent future disappointments.
A weekend is expected to be all about fun, and you can appear in style with a south bend Indiana limousine. Whether you are in city or traveling from another state, an experienced limo company can take you to your casino without any hassle. Just forget about locating the casino on the GPS. Do not worry about finding the hotel or even vehicle parking. Sit with the relaxation in a stretch south bend limo with your buddies and relish the journey, while an experienced limo driver takes you to the casino.
A highly demanded limousine for casino services in South Band is the Lincoln stretch limousine. Due to its seductively sleekness and quality clients consider it appropriate for casino and party night outs. Elegant and high-class, the stretch limousine subsequently has got a spacious and flexible interior accommodating perfectly up to 10 passengers and put at their convenience fully stocked bars, leather interior, mood lights, air-conditioning, CD/DVD music, DVD and LCD monitors.
Hire the South Bend Limousine service for your party and casino nights. They are perfect for any occasion either you are celebrating a bachelors party or a corporate event. South Bend Limousine service has top notch limousines for your needs ranging from Chrysler to 15 seat Party bus. The rates are very attractive and easily affordable. They provide professional drives which are second to none. They are truly able to assist you in staying in your budget when other limo services cant do it. They are always strived to fulfill your needs at the time of your event or your memorable event. To feel the difference visit the website of South bend limo.


About the Author:
Platinum Limousine provides the top quality limousines at affordable and attractive rates in South Bend, Indiana and the surrounding areas. For more details visit online at http://sb-platinumlimo.com/

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Wednesday, February 27, 2013

Study revises colorectal cancer risk down and other cancer risks up for women with Lynch Syndrome

Study revises colorectal cancer risk down and other cancer risks up for women with Lynch Syndrome [ Back to EurekAlert! ] Public release date: 26-Feb-2013
[ | E-mail | Share Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

50-60 percent colorectal cancer risk, 11 percent breast, 11 kidney, 9 percent bladder

Lynch Syndrome is a heritable genetic mutation that causes colorectal, endometrial and other cancers. A cooperative study that included the University of Colorado Cancer Center, published in this month's issue of the Journal of the National Cancer Institute, revises the risk of colorectal cancer down but other cancers up for women with Lynch Syndrome who have had endometrial cancer.

"This new information helps patient care in two important ways. First, it helps us counsel women with Lynch Syndrome who have had endometrial cancer about the magnitude of their future cancer risk, which turns out to be about 55 percent over the 20 years after diagnosis of their endometrial cancer. Second, it helps fill in the picture of the spectrum of cancers that are associated with Lynch Syndrome, which includes not only colorectal and endometrial cancers, but kidney, ureter, renal, pelvic, urinary, bladder and breast cancers in that order as well," says Dennis J. Ahnen, MD, CU Cancer Center investigator and professor of gastroenterology at the Denver VA Medical Center, one of the paper's co-authors.

The research group, which includes member from six centers, used data from 127 women included in the Colon Cancer Family Registry (CCFR). Ahnen notes that the CCFR is unique among cancer registries in that it not only collects information on patients with colorectal cancer and their treatment outcomes, but also routinely performs molecular characterization of these tumors, which can show which of these cancers are associated with Lynch Syndrome or other genetic abnormalities. Importantly, this molecular categorization allows researchers to discover which of the three possible pathways led to a patient's cancer the traditional chromosomal instability pathway accounts for about 80 percent of all colorectal cancers, and Lynch Syndrome combines with an epigenetic pathway to account for the remaining 20 percent.

"Knowing a cancer's genetic makeup allows us to ask questions not only about colorectal cancer in general, but about its molecular subtypes separately. These three types are included under the umbrella of colorectal cancer but have different prognoses and react differently to therapies. Effectively, they're quite different diseases," Ahnen says.

One of the study's important findings was an 11 percent lifetime risk for breast cancer after Lynch-associated endometrial cancer, 2.51 times the risk of women outside this population. Also elevated with Lynch Syndrome were lifetime risks of bladder (9 percent) and kidney (11 percent) cancers. But while the current study expands the spectrum of cancers associated with Lynch Syndrome, it also provides estimates of risk of colorectal cancer that are lower than previous estimates.

"When you think about it," Ahnen says, "most of the prior data on Lynch-associated colorectal cancer risk was from people referred to a high-risk clinic usually because of a strong family history of cancer. Of course, these people are likely to have higher cancer risk than the general population. The registry data minimizes this selection bias and allows us to look at a more representative cross-section of the colorectal cancer population. This cross-section shows a 50-60 percent lifetime risk of developing colorectal cancer in people with Lynch Syndrome, as opposed to earlier estimates of 70-80 percent risk."

"There are many remaining questions we can ask using the CCFR data," Ahnen says. "For example, what's the best way to screen people for Lynch Syndrome? Based on the risks the registry shows, should we screen all colorectal cancers for Lynch and then all family members of Lynch patients for the mutation or should we focus on some clinical subset of the population such as those with CRC at a young age? Likewise we can determine if colorectal cancers that arise from different molecular pathways are associated with different risk factor profiles, different prognoses or have different responses to available treatments."

To Ahnen, this specific study's findings are important but even more essential is the approach taken by the Colon Cancer Family Registry to collect and molecularly characterize these cancers. As cancer becomes an ever-longer list of related but distinctly different diseases, each perhaps with a molecular Achilles heel, the Colon Cancer Family Registry allows researchers like Ahnen to ask questions about treatment of these molecular subtypes that are rarely possible with cancer registries that treat, say, breast or prostate cancers as monolithic diseases.

Cancer is becoming seen as "cancers" and in many ways, the Colon Cancer Family Registry allows researchers in this field to lead the way.

###


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study revises colorectal cancer risk down and other cancer risks up for women with Lynch Syndrome [ Back to EurekAlert! ] Public release date: 26-Feb-2013
[ | E-mail | Share Share ]

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver

50-60 percent colorectal cancer risk, 11 percent breast, 11 kidney, 9 percent bladder

Lynch Syndrome is a heritable genetic mutation that causes colorectal, endometrial and other cancers. A cooperative study that included the University of Colorado Cancer Center, published in this month's issue of the Journal of the National Cancer Institute, revises the risk of colorectal cancer down but other cancers up for women with Lynch Syndrome who have had endometrial cancer.

"This new information helps patient care in two important ways. First, it helps us counsel women with Lynch Syndrome who have had endometrial cancer about the magnitude of their future cancer risk, which turns out to be about 55 percent over the 20 years after diagnosis of their endometrial cancer. Second, it helps fill in the picture of the spectrum of cancers that are associated with Lynch Syndrome, which includes not only colorectal and endometrial cancers, but kidney, ureter, renal, pelvic, urinary, bladder and breast cancers in that order as well," says Dennis J. Ahnen, MD, CU Cancer Center investigator and professor of gastroenterology at the Denver VA Medical Center, one of the paper's co-authors.

The research group, which includes member from six centers, used data from 127 women included in the Colon Cancer Family Registry (CCFR). Ahnen notes that the CCFR is unique among cancer registries in that it not only collects information on patients with colorectal cancer and their treatment outcomes, but also routinely performs molecular characterization of these tumors, which can show which of these cancers are associated with Lynch Syndrome or other genetic abnormalities. Importantly, this molecular categorization allows researchers to discover which of the three possible pathways led to a patient's cancer the traditional chromosomal instability pathway accounts for about 80 percent of all colorectal cancers, and Lynch Syndrome combines with an epigenetic pathway to account for the remaining 20 percent.

"Knowing a cancer's genetic makeup allows us to ask questions not only about colorectal cancer in general, but about its molecular subtypes separately. These three types are included under the umbrella of colorectal cancer but have different prognoses and react differently to therapies. Effectively, they're quite different diseases," Ahnen says.

One of the study's important findings was an 11 percent lifetime risk for breast cancer after Lynch-associated endometrial cancer, 2.51 times the risk of women outside this population. Also elevated with Lynch Syndrome were lifetime risks of bladder (9 percent) and kidney (11 percent) cancers. But while the current study expands the spectrum of cancers associated with Lynch Syndrome, it also provides estimates of risk of colorectal cancer that are lower than previous estimates.

"When you think about it," Ahnen says, "most of the prior data on Lynch-associated colorectal cancer risk was from people referred to a high-risk clinic usually because of a strong family history of cancer. Of course, these people are likely to have higher cancer risk than the general population. The registry data minimizes this selection bias and allows us to look at a more representative cross-section of the colorectal cancer population. This cross-section shows a 50-60 percent lifetime risk of developing colorectal cancer in people with Lynch Syndrome, as opposed to earlier estimates of 70-80 percent risk."

"There are many remaining questions we can ask using the CCFR data," Ahnen says. "For example, what's the best way to screen people for Lynch Syndrome? Based on the risks the registry shows, should we screen all colorectal cancers for Lynch and then all family members of Lynch patients for the mutation or should we focus on some clinical subset of the population such as those with CRC at a young age? Likewise we can determine if colorectal cancers that arise from different molecular pathways are associated with different risk factor profiles, different prognoses or have different responses to available treatments."

To Ahnen, this specific study's findings are important but even more essential is the approach taken by the Colon Cancer Family Registry to collect and molecularly characterize these cancers. As cancer becomes an ever-longer list of related but distinctly different diseases, each perhaps with a molecular Achilles heel, the Colon Cancer Family Registry allows researchers like Ahnen to ask questions about treatment of these molecular subtypes that are rarely possible with cancer registries that treat, say, breast or prostate cancers as monolithic diseases.

Cancer is becoming seen as "cancers" and in many ways, the Colon Cancer Family Registry allows researchers in this field to lead the way.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-02/uocd-src022613.php

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Raw results: Cena conquers Punk and Triple H returns to draw first blood

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Yes, But Michelle Malkin Can't Dance (Atlantic Politics Channel)

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iTunes in the Cloud looks to be hitting more of Europe with TV series, films

iTunes in the Cloud looks to be hitting parts of Europe with TV series, films

While stateside users might complain that we get all the good stuff in Europe first, Apple's iTunes in the Cloud for movies and TV shows has finally got around to rolling in to France and other parts of Europe, eons after it came out in the US. We confirmed that the new functionality works in France, which lets you buy films and TV shows from a computer, Apple TV or iOS device, then download it for free from the cloud on another. Others have reported by Twitter that it's working in Holland and Sweden as well, making it the first big move for the service since it rolled into the UK, Australia and Canada last summer. Until now, users in those nations were only able to download books, apps and music purchased in iTunes from the cloud. There's still no word from Apple about the move, however, and the list of supported countries hasn't been updated for those features -- so we'll enjoy it for now and hope Cupertino doesn't change its mind.

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