Among people aged 20 and below, the relative risk of pulmonary embolism was six times higher among people with inflammatory bowel disease compared with peers without IBD.February 22, 2011 ? Inflammatory bowel disease can more than double the risk of a blood clot in the legs or lungs, according to a new study.
Researcher Michael Kappelman, MD, University of North Carolina at Chapel Hill and his colleagues say the results confirm previous studies that have shown that IBD increases the risk of blood clots. Moreover, they suggest that the inflammatory bowel disease may be independent risk factor for the formation of blood clots, which in some cases may benefit from preventive therapy.
Inflammatory bowel disease (IBD) is a generic term covering a variety of intestinal disorders such as Crohn? s disease and ulcerative colitis.
After taking account of other factors known to increase the risk of blood clots, such as a broken bone, cancer, surgery or pregnancy, the researchers found that the risk of pulmonary embolism and deep vein thrombosis was twice as high in people with IBD compared to people without IBD.
But in this study, the researchers found the results showed that the risk of blood clots associated with inflammatory bowel disease was particularly high among young people.
The researchers found that children and adults with inflammatory bowel disease were twice as likely to develop a dangerous blood clot that develops in the leg known as deep vein thrombosis (DVT) or lungs, called pulmonary embolism (PE ).
In another analysis, the researchers also took into account the chronic diseases associated with an increased risk of blood clots, including heart disease, diabetes, congestive heart failure, and the use of hormone replacement therapy or antipsychotics. They found that the risk of blood clots is left up to 80% higher in people with inflammatory bowel disease.
The study compared the risk of pulmonary embolism and deep vein thrombosis among 49,799 Danish adults and children with IBD and more than 477,000 people without IBD Denmark, who were followed from 1980 to 2007.
These types of blood clots affect about two in 1,000 people in developed countries every year, and the risk increases with age.